Mendelian Randomization

Mendelian randomization with repeated measures of a time-varying exposure: an application of structural mean models

January 2022
Epidemiology

Joy Shi, Sonja A. Swanson, Peter Kraft, Bernard Rosner, Immaculata De Vivo, and Miguel A. Hernán

We describe instrumental variable analysis with a time-varying exposure, with an emphasis on the types of causal estimands that can be targeted, the assumptions required for identification, and the use of g-estimation of structural mean models to estimate these effects.